A study by Labenz et al in 2016 looked at patients with a history of chronic GERD (symptoms for greater than 1 year) and on adequate proton pump inhibitor therapy for over 1 year. In the 333 patients in this study, 46% of patients were having breakthrough symptoms twice a week and 20% had breakthrough 4-7 times a week. The patients were completely dissatisfied with their therapy. They were considered lost as this patient population is rarely offered a workup and anatomical correction of their disease, just more pills.
If your GERD pills are no longer working, never have, or your physician is increasing the dosage, it may be time to seek out a Reflux Center where you can be tested and give more options for management of the disease.